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Priv. Doz. Mag. Dr. Susanne Tollinger


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Biologin


Ausbildung


1987 – 1994
Studium der Mikrobiologie an der Naturwissenschaftlichen Fakultät der Universität Innsbruck, Austria. Diplomarbeit an der Abteilung für Medizinische Chemie und Biochemie, Universität Innsbruck: “Überwindung von Zytostatikaresistenzen in humanen Zelllinien“
Sponsion zur Magistra rerum naturalium

1994 - 1998
Doktoratsstudium an der Naturwissenschaftlichen Fakultät Innsbruck, Austria. Doktorarbeit an der Universitätsklinik für Dermatologie und Venerologie, Innsbruck, Austria: “Isolierung und Charakterisierung von Molekülen in unterschiedlichen Differenzierungsstadien von murinen dendritischen Zellen”
Promotion mit ausgezeichnetem Erfolg zur Doctorin rerum naturalium

2006                                                                                                                             Habilitation für das Fach Molekulare Zellbiologie an der Medizinischen Universität Innsbruck.

Weiterbildung


Projektmanagement, Tiroler Landeskrankenanstalten GmbH (TILAK), Innsbruck, Austria

Qualitätsmanagement in der Biotechnologie, JSW Research, Forschungslabor GmbH, Graz, Austria

Best of Biotech-Workshop, Center for Academic Spin-Offs (CAST), Innsbruck, Austria

Vortragstechnik, Universität Innsbruck, Innsbruck, Austria

Beruflicher Werdegang


1993-1995
Demonstrator, Medizinische Chemie und Biochemie, Universität Innsbruck, Austria
 
1998-1999
Postdoctoral fellow, Centro di Farmacologia Cellulare e Moleculare, CNR, Mailand, Italien, im Rahmen des „4th RTD framework“ der Europäischen Union

1999-2006 Forschungsassistent, Universitätsklinik für Dermatologie und Venerologie, Innsbruck, Austria

seit 3/2006
Laborleiterin, Universitätsklinik für Frauenheilkunde, Klinische Abteilung für gynäkologische Endokrinologie und Reproduktionsmedizin (Leiter: Univ.Prof. Dr. L. Wildt), Innsbruck, Austria

Preise


- 2004 Novartis Posterpreis der Österreichischen Gesellschaft für Dermatologie und Venerologie (ÖGDV)

- 2005 Österreichischer Preis für Dermatologie, UNILEVER HPC Austria

Publikationen - Originalarbeiten


Hofer, S., Pfeil, K., Niederegger, H., Ebner, S., Nguyen, V., Kremmer, E., Auffinger, M., Neyer, S., Fürhapter, C., Heufler, C.: Dendritic cells regulate T-cell deattachment through the integrin-interacting protein CYTIP. Blood, 107(3):1003-1009, 2006. I

Stoitzner, P., Stössl, H., Wankell, M., Hofer, S., Heufler, C., Werner, S., Romani, N.: Langerhans cells are strongly induced in the skin of transgenic mice overexpressing follistatin in the epidermis. Eur. J. Cell Biol. 84, 733-744, 2005.

Müller, H., Hofer, S., Kaneider, N., Neuwirt, H., Mosheimer, B., Mayer, G., Konwalinka, G., Heufler, C., Tiefenthaler, M.: The immunomodulator FTY720 interferes with effector functions of human monocyte-derived dendritic cells. Eur. J. Immunol. Vol 35: 533-545, 2005.

Tiefenthaler, M.*, Hofer, S.*, Ebner, S., Ivarsson, L., Neyer, S., Herold, M., Mayer, G., Fritsch, P., Heufler, C.: In vitro treatment of dendritic cells with tacrolimus: impaired T-cell activation and IP-10 expression. Nephrol. Dial. Transplant. 19: 533-560, 2004.

Leitner, K., Meyer, M., Leimbacher, W., Peterbauer, A., Hofer, S., Heufler, C., Müller, A., Heller, R., Werner, E., Thöny, B., Werner-Felmayer, G.: Low tetrahydrobiopterin biosynthetic capacity of human monocytes is caused by exon skipping in 6-pyruvoyl tetrahydropterin synthase. Biochem. J. Vol 373: 681-688, 2003.

Tiefenthaler, M., Bacher, N., Linert, H., Mühlmann, O., Hofer, S., Sepp, N., Amberger, A., Geisen, F., Obermoser, G., Konwalinka, G.: Apoptosis of CD34+ cells after incubation with sera of leukopenic patients with systemic lupus erythematosus. Lupus 12: 471-478, 2003.

Hofer, S., Ivarsson, L., Stoitzner, P., Auffinger, M., Rainer, C., Romani, N., Heufler, C.: Adenosine Slows Migration of Dendritic Cells but Does Not Affect Other Aspects of Dendritic Cell Maturation. J. Invest. Dermatol. 121/2: 300-307, 2003.

Boehm, T.*, Hofer, S.*, Winklehner, P., Kellersch, B., Geiger, C., Trockenbacher, A., Neyer, S., Fiegl, H., Ebner, S., Ivarsson, L., Schneider, R., Kremmer, E., Heufler, C., Kolanus, W.: Attenuation of cell adhesion in lymphocytes is regulated by CYTIP, a protein which mediates signal complex sequestration. EMBO J. 22(5): 1014-1024, 2003.

Ebner, S., Hofer, S., Nguyen, V., Fürhapter, C., Herold, M., Fritsch, P., Heufler, C., Romani, N.: A Novel Role for IL-3: Human Monocytes Cultured in the Presence of IL-3 and IL-4 Differentiate into Dendritic Cells That Produce Less IL-12 and Shift Th Cell Responses Toward a Th2 Cytokine Pattern. J. Immunol. 168: 6199-6207, 2002.

Schmuth, M., Wimmer, M. A., Hofer, S., Sztankay, A., Weinlich, G., Linder, D.M., Elias, P. M., Fritsch, P. O., Fritsch, E.: Topical steroid therapy for acute radiation dermatitis: a prospective, randomized, double blind study. British J. Dermatology, 146: 983-991, 2002.

Ebner, S., Neyer, S., Hofer, S., Nussbaumer, W., Romani, N., Heufler, C.: Generation of large numbers of human dendritic cells from whole blood passaged through leukocyte removal filters: an alternative to standard buffy coats. J. Immunol. Methods 252: 93-104, 2001.

Hofer, S., Rescigno, M., Granucci, F., Citterio, S., Francolini, M., Ricciardi-Castagnoli, P.: Differential activation of NF- κ B subunits in dendritic cells in response to Gram-negative bacteria and to lipopolysaccharide. Microbe. Infect. 3: 259-256, 2001.

Tiefenthaler, M., Marksteiner, R., Hofer, S., Neyer, S., Schuler, G., Nussenzweig, M., Schneider, R. and Heufler C.: M1204, a Novel 2`5` Oligoadenylate Synthetase with a Ubiquitin-Like Extension, Is Induced During Maturation of Murine Dendritic Cells. J. Immunol. 163: 760-765, 1999.

Hofmann, J., Utz, I., Spitaler, M., Hofer, S., Rybczynska, M., Beck, W.T., Herrmann DBJ., Grunicke, H.: Resistance to the new anti-cancer phospholipid ilmofosine (BM41 440). Br. J. Canc. 76 (7): 862 –869, 1997.

Hofmann, J., Gekeler, V., Ise, W., Noller, A., Mitterdorfer, J., Hofer, S., Utz, I., Gottwald, M., Boer, R., Glossmann, H., Grunicke, H.: Mechanism of action of Dexniguldipine-HCl (B8509-035), a new potent modulator of multidrug resistance. Biochem. Pharmacol. 49 (5), 603 -609, 1995.

Utz, I., Hofer, S., Regenass, U., Hilbe, W., Thaler, J., Grunicke, H., Hofmann, J.: The protein kinase C inhibitor CGP 41251, a staurosporine derivative with antitumor activity, reverses multidrug resistance. Int. J. Cancer. 57:104-110, 1994. 

Abstracts, Vorträge, Poster


Gollmann, G., Mueller, H., Neuwirt, H., Tripp, C., Hofer, S., Heufler, C., Karches-Boehm, M., Konwalinka, G., Tiefenthaler, M.: The S1P1-selective agonist SEW2871 reduces chemotaxis and modulates ERK1/2 activity in human dendritic cells. 7th International Conference on New Trends in Immunosuppression and Immunotherapy Berlin, Germany, voraussichtlich suppl. International Immunopharmacology, 2006
 
Hofer, S., Pfeil, K., Ebner, S., Nguyen, V., Niederegger, H., Heufler C.: Dendritic cells use CYTIP to actively regulate T-cell de-attachment. Annual Meeting of the "Arbeitsgemeinschaft Dermatologische Forschung – ADF, Arch. Dermatol. Res,  296: addendum, 2005
 
Mueller, H., Hofer, S., Neuwirt, H., Mayer, G., Heufler, C., Konwalinka, G., Tiefenthaler, M.: FTY720 interferes with effector functions and protein expression levels of S1P1 and S1P4 in human dendritic cells. World Congress of Nephrology, Singapore, Nephrology, Suppl.1, 2005
 
Mueller, H., Hofer, S., Heufler, C., Kaneider, N., Tancevski, I., Neuwirt, H., Konwalinka, G., Tiefenthaler, M., Mayer, G.: FTY720 interferes with effector functions and downregulates protein expression of S1P1 and S1P4 in human dendritic cells. Annual Meeting of the Austrian Society of Transplantation, Transfusion and Genetics, Alpbach, Austria, European Surgery, Suppl. 205, 2005
 
Mueller, H., Kaneider, N., Hofer, S., Mayer, G., Heufler, C., Konwalinka, G., Tiefenthaler, M.: Novel immunosuppressant agent FTY720 reduces chemotaxis of human monocyte-derived dendritic cells. World Congress of Nephrology, Berlin, Germany, Nephrol. Dial. Transplant, Suppl.4, 2003
 
Hofer, S., Ivarsson, L., Neyer, S., Romani, N., Heufler, C. : Adenosine delays migration of dendritic cells. Annual Meeting of the Arbeitsgemeinschaft Dermatologische Forschung (ADF), Berlin, Germany, Arch Dermatol Res, 294: addendum, 2002
 
Ebner, S., Hofer, S., Nguyen, V., Fürhapter, C., Herold, M., Fritsch, P., Heufler, C., Romani, N.: Interleukin-3 modifies the capacity of human monocyte-derived dendritic cells to induce helper T cell responses: Shift towards a Th2 cytokine secretion pattern. Annual Meeting of the Arbeitsgemeinschaft Dermatologische Forschung (ADF), Berlin, Germany, Arch Dermatol Res, 294: addendum, 2002
 
Hofmann, J., Utz, I., Spitaler, M., Hofer, S., Grunicke, H.: Resistance to the new anticancer phospholipid ilmofosine (BM 41 440). J. Cancer Res. Clin. Oncol., 121, Suppl. 2, A57/T42, 1995
 
Utz, I., Hofer, S., Regenass, U., Spitaler, M., Grunicke, H., Hofmann, J.:  The protein kinase C inhibitor CGP 41251, a staurosporine derivative with antitumor  activity, reverses multidrug resistance. Annals of Oncology, Vol. 5, Suppl. 5, 339, 1994
 
Utz, I., Hofer, S., Regenass, U., Grunicke, H., Hofmann, J.:  The protein kinase C inhibitor CGP 41251, a staurosporine derivative with antitumor  activity, reverses multidrug resistance. J. Cell Biochem., Supplement 18D, QZ409, Wiley-Liss, 1994

Hofer, S., Pfeil, K., Niederegger, H., Ebner, S.,  Nguyen, V., Auffinger, M., Neyer, S., Fürhapter, C.,  Heufler C.: Dendritic cells regulate T-cell de-attachment through CYTIP. Immunologisches Seminar, Innsbruck, Austria, 2005
 
Hofer, S., Pfeil, K., Niederegger, H., Ebner, S.,  Nguyen, V., Auffinger, M., Neyer, S., Fürhapter, C.,  Heufler C.: Dendritic cells use CYTIP to actively regulate T-cell de-attachment. 8th International Symposium on Dendritic Cells,  Brügge, Belgium, 2004
 
Hofer, S.,  Winklehner, P., Böhm, T.,  Ebner, S., Ivarsson, L., Kolanus, W., Heufler, C.:  CYTIP, a novel molecule upregulated during DC maturation regulates integrin mediated adhesion,  7th International Symposium on Dendritic Cells,  Bamberg,  Germany, 2002
 
Hofer, S., Ivarsson L., Romani N., Heufler C:  Adenosine delays migration of dendritic cells,  Erlangen-Würzburg-Innsbruck (EWI) - DC - meeting, Innsbruck, Austria, 2002
 
Hofer, S., Ebner, S., Neyer, S., Heufler, C.: Differential screening of mature versus immature DC. Erlangen-Würzburg-Innsbruck (EWI) - DC - meeting, Schloß Zeilitzheim, Germany, 2000

Hofer, S.: Dendritic cells regulate T-cell deattachment through the integrin-interacting protein CYTIP. Jahrestagung der Österreichischen Gesellschaft für Dermatologie und Venerologie (ÖGDV) Verleihung des Unileverpreises, Wien, Austria, 2005
 
Hofer, S.: CYTIP, a cytosolic molecule induced during dendritic cell maturation. A regulatory molecule for integrin mediated cell adhesion and for T cell screening?  Univ. - Klinik. für Dermatologie, Innsbruck, Austria, 2004
 
Hofer, S.: Dendritic cells induce impaired T-cell activation after in vitro application of tacrolimus (FK506).  Univ. - Klinik. für Dermatologie, Innsbruck, Austria, 2002
 
Hofer, S.: Isolation of a novel molecule expressed in mature dendritic cells. Universita di  Milano, Farmacologia, Italia, 1998
 
Hofer, S., Pfeil, K., Ebner, S., Nguyen, V., Niederegger, H., Auffinger, M., Neyer, S., Fürhapter, C., Niederegger, H., Heufler C.: Dendritic cells use CYTIP to actively regulate T-cell de-attachment. 9th International Workshop on Langerhans Cells, Funchal / Madeira, 2005
 
Stoitzner, P.,  Stössel, H., Wankell, M., Hofer, S.,  Heufler, C.,  Werner, S., Romani, N.: Langerhans cells are strongly reduced in the skin of transgenic mice overexpressing follistatin in the epidermis. 9th International Workshop on Langerhans Cells, Funchal, Madeira, 2005
 
Hofer, S., Pfeil, K., Ebner, S., Nguyen, V., Niederegger, H., Auffinger, M., Neyer, S., Fürhapter, C., Niederegger, H., Heufler C.: Dendritic cells use CYTIP to actively regulate T-cell de-attachment. 8th International Symposium on Dendritic Cells. Brugge, Belgium, 2004
 
Hofer, S., Pfeil, K., Ebner, S., Nguyen, V., Niederegger, H., Heufler, C.: Dendritic cells use CYTIP to actively regulate T-cell de-attachment. Österreichische Gesellschaft für Dermatologie und Venerologie (ÖGDV),  Grazer Congress, 2004
 
Hofer, S., Auffinger, M., Nguyen, V., Heufler, C.: Integrin dependent interaction between human DC and T-cells is regulated by CYTIP a protein induced by DC maturation. 7th International Workshop on Langerhans Cells, Tokyo, Japan, 2003
 
Hofer, S., Winklehner, P., Böhm, T., Ebner, S., Ivarsson, L., Kolanus, W, Heufler, C.: CYTIP, a novel molecule upregulated during DC maturation regulates integrin mediated adhesion. 7th International Symposium on Dendritic Cells, Bamberg, Germany , 2002
 
Hofer, S., Ivarsson, L., Stoitzner, P., Rainer, C., Auffinger, M., Romani, N., Heufler, C.: Adenosine delays migration of dendritic cells. 7th International Symposium on Dendritic Cells. Bamberg, Germany, 2002
 
Hofer, S., Ivarsson, L., Neyer, S., Heufler, C. : The adenosine receptors A2a and A3 are differentially expressed during dendritic cell maturation. 7th International Workshop on Langerhans Cells, Stresa, Italy, 2001
 
Ivarsson, L., Winklehner, P., Trockenbacher, A., Neyer, S., Fiegl, H., Hofer, S., Ebner, S., Böhm, T., Kolanus, W., Schneider, R., Heufler, C.: Differentially expressed molecules in dendritic cells: integrin adhesion dependent membrane translocation of CYTIP, an upregulated novel Cytohesin-1 interacting Protein. 7th International Workshop on Langerhans Cells, Stresa, Italy, 2001
 
Tiefenthaler, M., Hofer, S., Neyer, S., Heufler, C.: Dendritic cells downregulate IP-10, Dectin-1 and DC-SIGN in response to the immunosuppressive drug tacrolimus (FK506): 7th International Workshop on Langerhans Cells, Stresa, Italy, 2001
 
Tiefenthaler, M., Hofer, S., Herold, M., Neyer, S., Mayer, G., Heufler, C.: Dendritic cells downregulate IP-10, Dectin-1 and DC-SIGN in response to the immunosuppressive drug tacrolimus (FK506). Weltkongress für Nephrologie, San Francisco, USA, 2001
 
Winklehner, P., Trockenbacher, A., Neyer, S., Fiegl, H., Hofer, S., Ivarsson, L., Ebner, S., Böhm, T., Kolanus, W., Schneider, R., Heufler, C.: Differentially expressed molecules in dendritic cells: integrin adhesion dependent membrane translocation of CYTIP, an upregulated novel Cytohesin-1 interacting protein. Jahrestagung der Österreichischen Gesellschaft für Allergologie und Immunologie (ÖGAI), Vienna, Austria, 2001
 
Hofer, S., Ebner, S., Neyer, S., Nussbaumer, W., Romani, N., Heufler, C.: Generation of large numbers of human dendritic cells from leukocyte removal filters for whole blood. 6th International Symposium on Dendritic Cells, Port Douglas, Australia, 2000
 
Hofer, S., Fiegl, H.,  Winklehner, P., Trockenbacher ,A., Neyer, S., Ebner, S.,  Schneider, R.,  Heufler,C.: Cytohesin binding protein 1 of dendritic cells is differentially upregulated with different stimuli for maturation. Jahrestagung der Österreichischen Gesellschaft für Allergologie und Immunologie (ÖGAI), Vienna, Austria, 2000
 
Tiefenthaler, M., Marksteiner, R., Hofer, S., Koch, F., Schuler, G., Nussenzweig, M., Schneider, R., Heufler, C.: M1204, a novel molecule expressed during the maturation process of murine dendritic cells. 5th International Symposium on Dendritic Cells, Pittsburgh, 1999
 
Hofer, S., Noggler, M., Koch, F., Schuler, G., Heufler, C. : Isolation of a novel molecule expressed in mature dendritic cells. 4th International Symposium on Dendritic Cells, Venice (Lido), Italy, 1996
 
Hofmann, J., Utz, I., Spitaler, M., Hofer, S., Schubert, C., Grunicke, H.: Involvement of P-glycoprotein in ilmofosine resistance.  23rd Meeting of the European Biochemical Societies, Basel, 1995
 
Hofmann, J., Gekeler, V., Ise, W., Mitterdorfer, J., Utz, S., Hofer, S., Grunicke, H.: Mechanism of the new potent multidrug resistance modulatordexniguldipine-HCl (B8509- 035). International Meeting Growth Control and Therapy of Cancer, 79, Budapest, Hungary, 1994
 
Utz, I., Hofer, S., Regenass, U., Hilbe, W., Grunicke, H., and Hofmann, J.:  The protein kinase C inhibitor CGP 41251, a staurosporine derivative with antitumor  activity, reverses multidrug resistance. International Meeting Growth Control and Therapy of Cancer, 38, Budapest, Hungary, 1994
 
Utz, I., Hofer, S., Regenass, U., Hofmann, J., and Grunicke, H.: The protein kinase C inhibitor CGP 41 251, a staurosporine derivative, reverses multidrug  resistance. Gemeinsame Jahrestagung der Österr. Gesellschaft für Biochemie u. Österr. Gesellschaft für Genetik und Gentechnik, 1999




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